Association of HMGB1 levels in synovial fluid with the severity of temporomandibular joint osteoarthritis.

ABSTRACT:

Background

HMGB1 usually serves as a damage-associated molecular pattern (DAMP) molecule (also known as alarmin) that regulates the inflammatory and immune responses via different receptors or direct uptake. Numerous studies have reported the association between HMGB1 and inflammatory diseases; however, its role in temporomandibular joint (TMJ) osteoarthritis (OA) has not been elucidated. In this retrospective study, we aimed to investigate HMGB1 levels in the synovial fluid (SF) in patients with TMJOA and TMID, their correlation with TMJOA and TMID severity, and the therapeutic effect of sodium hyaluronate (hyaluronic acid, HA) on TMJOA.

Methods

SF samples were analyzed for 30 patients with TMJ internal derangement (TMJID) and TMJOA, along with visual analog scale (VAS) sco

SUBMITTER: Shao B 

PROVIDER: S-EPMC10007792 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature