DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord.

ABSTRACT:

Background

The biological tube is a basal biology structure distributed in all multicellular animals, from worms to humans, and has diverse biological functions. Formation of tubular system is crucial for embryogenesis and adult metabolism. Ascidian Ciona notochord lumen is an excellent in vivo model for tubulogenesis. Exocytosis has been known to be essential for tubular lumen formation and expansion. The roles of endocytosis in tubular lumen expansion remain largely unclear.

Results

In this study, we first identified a dual specificity tyrosine-phosphorylation-regulated kinase 1 (DYRK1), the protein kinase, which was upregulated and required for ascidian notochord extracellular lumen expansion. We demonstrated that DYRK1 interacted with and phosphorylated one of the endocy

SUBMITTER: Ouyang X 

PROVIDER: S-EPMC10007804 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature