[¹⁸F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.

ABSTRACT:

Objectives

Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PET ligand to monitor reactive astrogliosis in a transgenic mouse model of Alzheimer`s disease (AD). Furthermore, we performed a pilot study in patients with a range of neurodegenerative and neuroinflammatory conditions.

Methods

A cross-sectional cohort of 24 transgenic (PS2APP) and 25 wild-type mice (age range: 4.3-21.0 months) underwent 60 min dynamic [¹⁸F]fluorodeprenyl-D2 ([¹⁸F]F-DED), static 18 kDa translocator protein (TSPO, [¹⁸F]GE-180) and β-amyloid ([¹⁸F]florbetaben) PET imaging. Quantification was performed

SUBMITTER: Ballweg A 

PROVIDER: S-EPMC10007845 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature