Prognostic and immunological role of alpha-L-fucosidase 2 (FUCA2) in hepatocellular carcinoma

ABSTRACT:

Background

This study investigated the prognostic and immunological significance of alpha-L-fucosidase 2 (FUCA2) in hepatocellular cancer (HCC).

Methods

The expression of FUCA2 and its clinical and prognostic values were explored across several databases, namely the University of Alabama Cancer Database, The Cancer Genome Atlas, Gene Expression Profiling Interactive Analysis, and the Human Protein Atlas. The prognostic relevance of FUCA2 was investigated using Kaplan-Meier curves, nomograms, and Cox analysis. The “limma” package in R was used to identify differentially expressed genes between high and low FUCA2 expression. A protein interaction network was established using the Search Tool for the Retrieval of Interacting Genes (STRING), whereas hub genes and clustering m

SUBMITTER:  

PROVIDER: S-EPMC10007884 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature