A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma.

ABSTRACT:

Background

Centromere proteins (CENPs) form a large protein family. Sixteen proteins in this family are positioned at the centromere throughout the cell cycle. The overexpression of CENPs is common in many cancers and predicts a poor prognosis. However, a comprehensive analysis of CENPs expression has not been conducted, and their clinical significance in lung adenocarcinoma (LUAD) is unclear.

Methods

We investigated the expression differences of the CENP family in LUAD using The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) cohorts. Kaplan-Meier curve survival analysis was performed to assess their independent prognostic values. We then tested 5 clinical LUAD specimens by quantitative real time polymerase chain reaction (qRT-PCR). The risk model was c

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10007894 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature