Extracellular matrix-based gene signature for predicting prognosis in colon cancer and immune microenvironment.

ABSTRACT:

Background

The extracellular matrix (ECM) plays a vital role in progression, expansion, and prognosis of malignancies. In this study, we aimed to explore a novel ECM-based prognostic model for patients with colon cancer (CC).

Methods

ECM-related genes were obtained from Molecular Signatures database. Differential expression analysis was performed using the CC dataset from The Cancer Genome Atlas (TCGA) database. Four ECM-related genes related to overall survival were identified using the Cox regression and LASSO analysis. Then an ECM-related signature was developed and verified in three independent CC cohorts (GSE33882, GSE39582 and GSE29621) from the Gene Expression Omnibus (GEO). A prognostic nomogram was developed incorporating the ECM-related gene signature with clinical

SUBMITTER: Chai R 

PROVIDER: S-EPMC10007896 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature