Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system.

ABSTRACT:

Background

The clinical utility of molecular profiling and targeted therapies for neuro-oncology patients outside of clinical trials is not established. We aimed at investigating feasibility and clinical utility of molecular profiling and targeted therapy in adult patients with advanced tumors in the nervous system within a prospective observational study.

Methods

molecular tumor board (MTB)@ZPM (NCT03503149) is a prospective observational precision medicine study for patients with advanced tumors. After inclusion of patients, we performed comprehensive molecular profiling, formulated ranked biomarker-guided therapy recommendations based on consensus by the MTB, and collected prospective clinical outcome data.

Results

Here, we present initial data of 661 adult patient

SUBMITTER: Renovanz M 

PROVIDER: S-EPMC10007909 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature