Silencing proline-rich coiled-coil 2C inhibit the proliferation and metastasis of liver cancer cells.

ABSTRACT:

Background

Proline-rich coiled-coil 2C (PRRC2C) is located in the chromosome region lq where hepatocellular carcinoma (HCC) frequently undergoes genomic fragment amplification, but its role in HCC is unknown. In this study, we aimed to explore the correlation of PRRC2C with HCC diagnosis and progression, as well as its influence on the biological behavior of HCC cells.

Methods

The Cancer Genome Atlas (TCGA) RNA-sequencing datasets of 371 cases of primary liver cancer and 50 normal liver tissue specimens were obtained to analyze correlation between PRRC2C expression and HCC staging, grades, and overall survival. After confirming expression of PRRC2C in HCC cells, PRRC2C silencing was performed. Celigo cell counting, cell clone formati

SUBMITTER: Zhang K 

PROVIDER: S-EPMC10007939 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature