Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (Carassius carassius).

ABSTRACT: The crucian carp (Carassius carassius) can survive complete oxygen depletion (anoxia) for several months at low temperatures, making it an excellent model for studying molecular adaptations to anoxia. Still, little is known about how its global proteome responds to anoxia and reoxygenation. By applying mass spectrometry-based proteome analyses on brain, heart and liver tissue from crucian carp exposed to normoxia, five days anoxia, and reoxygenation, we found major changes in particularly cardiac and hepatic protein levels in response to anoxia and reoxygenation. These included tissue-specific differences in mitochondrial proteins involved in aerobic respiration and mitochondrial membrane integrity. Enzymes in the electron transport system (ETS) decreased in heart and increased mass

SUBMITTER: Johansen A 

PROVIDER: S-EPMC10007964 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature