An fMRI-Based Brain Marker of Individual Differences in Delay Discounting.

ABSTRACT: Individual differences in delay discounting-how much we discount future compared to immediate rewards-are associated with general life outcomes, psychopathology, and obesity. Here, we use machine learning on fMRI activity during an intertemporal choice task to develop a functional brain marker of these individual differences in human adults. Training and cross-validating the marker in one dataset (Study 1, N = 110 male adults) resulted in a significant prediction-outcome correlation (r = 0.49), generalized to predict individual differences in a completely independent dataset (Study 2: N = 145 male and female adults, r = 0.45), and predicted discounting several weeks later. Out-of-sample responses of the functional brain marker, but not discounting behavior itsel

SUBMITTER: Koban L 

PROVIDER: S-EPMC10008056 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature