Distinct platelet crosstalk with adaptive and innate immune cells after adenoviral and mRNA vaccination against SARS-CoV-2.

ABSTRACT:

Background

Genetic-based COVID-19 vaccines have proved to be highly effective in reducing the risk of hospitalization and death. Because they were first distributed in a large-scale population, the adenoviral-based vaccines were linked to a very rare thrombosis with thrombocytopenia syndrome, and the interplay between platelets and vaccinations increasingly gained attention.

Objectives

The objective of this article was to study the crosstalk between platelets and the vaccine-induced immune response.

Methods

We prospectively enrolled young healthy volunteers who received the mRNA-based vaccine, BNT162b2 (n = 15), or the adenovirus-based vaccine, AZD1222 (n = 25) and studied their short-term platelet and immune response before and after vaccine injections. In a separate

SUBMITTER: Lombardi L 

PROVIDER: S-EPMC10008173 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature