Comprehensive analysis of COMMD10 as a novel prognostic biomarker for gastric cancer.

ABSTRACT:

Background

COMMD10 has an important role in the development of certain tumors, but its relevance to gastric cancer (GC) is unclear. The purpose of this study is to investigate the difference of COMMD10 expression in gastric adenocarcinoma (STAD) and analyze the correlation between COMMD10 expression and prognosis of STAD patients.

Methods

The expression levels of COMMD10 between STAD and normal tissues were explored using the The Cancer Genome Atlas (TCGA) database. In addition, the expression of COMMD10 in GC was further validated by immunohistochemistry (IHC) staining, qRT-PCR and Western blot. Dot blot experiments were used for exploring m6A expression levels in tissues with high and low COMMD10 expression. Kaplan-Meier analysis and COX regression analysis were used to ex

SUBMITTER: Zhao W 

PROVIDER: S-EPMC10008319 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature