Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases.

ABSTRACT:

Objectives

Depression is a prevalent psychiatric disorder. Treatment of depression is still a challenge due to the lack of response of some patients to a variety of available medications and side effects. Isatin is an interesting molecule with diversified biological effects. It also participates in many synthetic reactions, as a precursor molecule. In this study, a new series of N-alkyl and N-benzyl isatin derivatives bearing Schiff bases were synthesized and screened for antidepressant activities in mice.

Materials and methods

The synthesis was initiated by N-alkylation and N-benzylation of isatin by an alkylation reaction to give N-substituted isatins. 2-(Benzyloxy) benzohydrazide derivatives were synthesized by treating methyl2-hydroxybenzoate with benzyl bromide or 4-chl

SUBMITTER: Mesripour A 

PROVIDER: S-EPMC10008399 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature