Investigation of SARS-CoV-2 seroprevalence in relation to natural infection and vaccination between October 2020 and September 2021 in the Czech Republic: a prospective national cohort study.

ABSTRACT:

Objective

Examine changes in SARS-CoV-2 seropositivity before and during the national vaccination campaign in the Czech Republic.

Design

Prospective national population-based cohort study.

Setting

Masaryk University, RECETOX, Brno.

Participants

22 130 persons provided blood samples at two time points approximately 5-7 months apart, between October 2020 and March 2021 (phase I, before vaccination), and between April and September 2021 (during vaccination campaign).

Outcome measures

Antigen-specific humoral immune response was analysed by detection of IgG antibodies against the SARS-CoV-2 spike protein by commercial chemiluminescent immunoassays. Participants completed a questionnaire that included personal information, anthropometric data, self-reported r

SUBMITTER: Thon V 

PROVIDER: S-EPMC10008433 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature