Relationship between telomere shortening and early subjective depressive symptoms and cognitive complaints in older adults.

ABSTRACT: Telomere length (TL) has been reported to be associated with depression and cognitive impairment in elderly. Early detection of depression and cognitive impairment is important to delay disease progression. Therefore, we aimed to identify whether TL is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly subjects. This study was a multicenter, outcome assessor-blinded, 24-week, randomized controlled trial (RCT). Measurement of questionnaire and physical activity scores and blood sample analyses were performed at baseline and after six months of follow-up in all study participants. Linear regression analyses were performed to identify whether early subjective depressive symptoms, cognitive complaints, and several blood biomarkers are associated

SUBMITTER: Han MH 

PROVIDER: S-EPMC10008503 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature