Mechanisms of spontaneous Ca²⁺ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation.

ABSTRACT: Intracellular calcium (Ca²⁺ ) cycling is tightly regulated in the healthy heart ensuring effective contraction. This is achieved by transverse (t)-tubule membrane invaginations that facilitate close coupling of key Ca²⁺ -handling proteins such as the L-type Ca²⁺ channel and Na⁺ -Ca²⁺ exchanger (NCX) on the cell surface with ryanodine receptors (RyRs) on the intracellular Ca²⁺ store. Although less abundant and regular than in the ventricle, t-tubules also exist in atrial myocytes as a network of transverse invaginations with axial extensions known as the transverse-axial tubule system (TATS). In heart failure and atrial fibrillation, there is TATS remodelling that is associated with aberrant Ca²⁺ -handling and Ca

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10008525 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature