Mitochondrial cellular organization and shape fluctuations are differentially modulated by cytoskeletal networks.

ABSTRACT: The interactions between mitochondria and the cytoskeleton have been found to alter mitochondrial function; however, the mechanisms underlying this phenomenon are largely unknown. Here, we explored how the integrity of the cytoskeleton affects the cellular organization, morphology and mobility of mitochondria in Xenopus laevis melanocytes. Cells were imaged in control condition and after different treatments that selectively affect specific cytoskeletal networks (microtubules, F-actin and vimentin filaments). We observed that mitochondria cellular distribution and local orientation rely mostly on microtubules, positioning these filaments as the main scaffolding of mitochondrial organization. We also found that cytoskeletal networks mold mitochondria shapes in distinct ways: while microtubu

SUBMITTER: Fernandez Casafuz AB 

PROVIDER: S-EPMC10008531 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature