DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson's disease.

ABSTRACT: Although subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson's disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes for optimizing DBS parameter settings, which may contribute to treatment inefficacies. One parameter that could aid DBS efficacy is the orientation of current administered, albeit the precise mechanisms underlying optimal contact orientations and associated clinical benefits are not well understood. Herein, 24 PD patients received monopolar stimulation of the left STN during magnetoencephalography and standardized movement protocols to interrogate the directional specificity of STN-DBS current administration on accelerometer metrics of fine hand mov

SUBMITTER: Spooner RK 

PROVIDER: S-EPMC10008535 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature