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Microporous PdCuB nanotag-based electrochemical aptasensor with Au@CuCl₂ nanowires interface for ultrasensitive detection of PD-L1-positive exosomes in the serum of lung cancer patients.

ABSTRACT: Programmed cell death ligand 1 protein-positive (PD-L1⁺) exosomes have been found to be a potential biomarker for the diagnosis of non-small cell lung cancer (NSCLC). However, the development of highly sensitive detection technique for PD-L1⁺ exosomes is still a challenge in clinical applications. Herein, a sandwich electrochemical aptasensor based on ternary metal-metalloid palladium-copper-boron alloy microporous nanospheres (PdCuB MNs) and Au@CuCl₂ nanowires (NWs) was designed for the detection of PD-L1⁺ exosomes. The excellent peroxidase-like catalytic activity of PdCuB MNs and the high conductivity of Au@CuCl₂ NWs endow the fabricated aptasensor with intense electrochemical signal, thus enabling the detection of low abundance exos

SUBMITTER: Chang L

PROVIDER: S-EPMC10008610 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

Microporous PdCuB nanotag-based electrochemical aptasensor with Au@CuCl₂ nanowires interface for ultrasensitive detection of PD-L1-positive exosomes in the serum of lung cancer patients.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Microporous PdCuB nanotag-based electrochemical aptasensor with Au@CuCl2 nanowires interface for ultrasensitive detection of PD-L1-positive exosomes in the serum of lung cancer patients.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Microporous PdCuB nanotag-based electrochemical aptasensor with Au@CuCl₂ nanowires interface for ultrasensitive detection of PD-L1-positive exosomes in the serum of lung cancer patients.