Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression.

ABSTRACT: At the group level, antidepressant efficacy of rTMS targets is inversely related to their normative connectivity with subgenual anterior cingulate cortex (sgACC). Individualized connectivity may yield better targets, particularly in patients with neuropsychiatric disorders who may have aberrant connectivity. However, sgACC connectivity shows poor test-retest reliability at the individual level. Individualized resting-state network mapping (RSNM) can reliably map inter-individual variability in brain network organization. Thus, we sought to identify individualized RSNM-based rTMS targets that reliably target the sgACC connectivity profile. We used RSNM to identify network-based rTMS targets in 10 healthy controls and 13 individuals with traumatic brain injury-associated depression (TBI-D).

SUBMITTER: Siddiqi SH 

PROVIDER: S-EPMC10008633 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature