CD83 expression characterizes precursor exhausted T cell population.

ABSTRACT: T cell exhaustion is a main obstacle against effective cancer immunotherapy. Exhausted T cells include a subpopulation that maintains proliferative capacity, referred to as precursor exhausted T cells (T_PEX). While functionally distinct and important for antitumor immunity, T_PEX possess some overlapping phenotypic features with the other T-cell subsets within the heterogeneous tumor-infiltrating T-lymphocytes (TIL). Here we explore surface marker profiles unique to T_PEX using the tumor models treated by chimeric antigen receptor (CAR)-engineered T cells. We find that CD83 is predominantly expressed in the CCR7⁺PD1⁺ intratumoral CAR-T cells compared with the CCR7^-PD1⁺ (terminally differentiated) and CAR-negative (b

SUBMITTER: Wu Z 

PROVIDER: S-EPMC10008643 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature