Clinical significance of MYC family protein expression in surgically resected high-grade neuroendocrine carcinoma of the lung.

ABSTRACT:

Objectives

MYC family genes including MYC, MYCN, and MYCL are amplified and overexpressed as oncogenic drivers in high-grade neuroendocrine carcinoma of the lung (HGNEC), but little is known about their clinical significance. This study evaluated the prognostic impact of MYC family protein expression in patients with surgically resected HGNEC.

Methods

Immunohistochemical analyses were performed on 83 resected specimens of HGNEC using antibodies against MYC family proteins (c-MYC, n-MYC, and l-MYC). When nuclear staining of any intensity in ≥10% of tumor cells showed immunoreactivity with any one or more of c-MYC, n-MYC, or l-MYC, the specimens were defined as MYC family-positive.

Results

A total of 83 patients were analyzed. MYC family-positive status was observed in

SUBMITTER: Oshima Y 

PROVIDER: S-EPMC10008680 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature