The Emerging Role of Super-enhancers as Therapeutic Targets in The Digestive System Tumors.

ABSTRACT: Digestive system tumors include malignancies of the stomach, pancreas, colon, rectum, and the esophagus, and are associated with high morbidity and mortality. Aberrant epigenetic modifications play a vital role in the progression of digestive system tumors. The aberrant transcription of key oncogenes is driven by super-enhancers (SEs), which are characterized by large clusters of enhancers with significantly high density of transcription factors, cofactors, and epigenetic modulatory proteins. The SEs consist of critical epigenetic regulatory elements, which modulate the biological characteristics of digestive system tumors including tumor cell identity and differentiation, tumorigenesis, environmental response, immune response, and chemotherapeutic resistance. The core transcription regula

SUBMITTER: Li XP 

PROVIDER: S-EPMC10008685 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature