Re-analysis of ventilator-free days (VFD) in acute respiratory distress syndrome (ARDS) studies.

ABSTRACT:

Background

Over recent decades, improvements in healthcare have reduced mortality and morbidity rates in many conditions. This has resulted, in part, from the identification of effective interventions in randomised trials, and in conducting such trials, a composite outcome measure (COM) with multiple components will increase event rates, which allows study completion with a smaller sample size. In critical care research, the COM "ventilator-free days" (VFD) combines mortality and duration of mechanical ventilation (MV) into a single continuous measure, which can be analysed in a variety of ways. This study investigates the usefulness of Poisson and two-part Poisson models compared to t-distribution for the analysis of VFD.

Methods

Data from four studies (ALbuterol for the Tr

SUBMITTER: Verghis RM 

PROVIDER: S-EPMC10008713 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature