Resolvin D1 improves allograft osteointegration and directly enhances osteoblasts differentiation.

ABSTRACT:

Introduction

Allografts are the most common bone grafts for repairing osseous defects. However, their use is associated with an increased risk for infections, donor disease transmission and osteointegration deficiency. Resolvin D1 (RvD1) is an endogenous lipid with a scientifically proven pivotal role in inflammation resolution and osteoclastogenesis inhibition. Yet, its biological relevance as a potential bone regenerative drug has been scarcely studied. Here, we aim to investigate the RvD1 effect on allograft osteointegration in the alveolar bone regeneration (ABR) murine model.

Methods

ABR model consisted of osseous defects that were generated by the extraction of the maxillary first molar in C57BL/6 mice. The sockets were filled with allograft and analyzed via RNA

SUBMITTER: Pinto N 

PROVIDER: S-EPMC10008843 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature