Dataset Information

Schizophrenia and oxidative stress from the perspective of bibliometric analysis.

ABSTRACT:

Background

A growing number of studies has implicated oxidative stress in the pathophysiology of psychiatric disorders including schizophrenia. The aim of this study was to explore the field of schizophrenia and oxidative stress-related research from a bibliometric perspective.

Methods

All relevant publications on schizophrenia and oxidative stress were obtained from Web of Science Core Collection (WOSCC) database from its inception date to November 8, 2022. VOSviewer software was used to examine co-authorships and co-occurring keywords. R software was used to present the main characteristics of publications and cooperation frequency among countries. CiteSpace was used to investigate keywords with the strongest citation bursts.

Results

A total of 3,510 publications on schizophrenia and oxidative stress were included. The United States had the largest number of publications (26.1%), and international collaborations. University of Melbourne was the most productive institution, while Schizophrenia Research was the most productive journal in this field. Apart from "schizophrenia" and "oxidative stress", the terms "prefrontal cortex", "brain" and "nitric oxide" were among the most frequently used keywords.

Conclusions

In conclusion, research on the association between oxidative stress and schizophrenia has received growing attention in the academic literature that is expected to continue its upward trajectory during the next two decades. Existing research suggests there has been a transition from research focused on pathways to animal models, and subsequently to clinical applications. Intervention studies on oxidative stress and schizophrenia are likely to be an important focus of related work in the near future.

SUBMITTER: Chen MY

PROVIDER: S-EPMC10008861 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Schizophrenia and oxidative stress from the perspective of bibliometric analysis.

Chen Meng-Yi MY Zhang Qinge Q Liu Yu-Fei YF Zheng Wan-Ying WY Si Tong Leong TL Su Zhaohui Z Cheung Teris T Jackson Todd T Li Xiao-Hong XH Xiang Yu-Tao YT

Frontiers in psychiatry 20230227

<h4>Background</h4>A growing number of studies has implicated oxidative stress in the pathophysiology of psychiatric disorders including schizophrenia. The aim of this study was to explore the field of schizophrenia and oxidative stress-related research from a bibliometric perspective.<h4>Methods</h4>All relevant publications on schizophrenia and oxidative stress were obtained from Web of Science Core Collection (WOSCC) database from its inception date to November 8, 2022. VOSviewer software was ...[more]

PMID: 36923522

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Project description:BackgroundSchizophrenia is a chronic mental illness that affects millions of individuals worldwide. The etiological origin of schizophrenia is heterogeneous, but it has been shown to be associated with dysfunction in serotonin activity, serotonin receptors, and serotonin metabolism in the brain. Bibliometric analysis is a tool used to scrutinise and analyse research activities and evidence in a specific research area. No existing bibliometric analyses have considered both serotonin and schizophrenia.MethodsWe conducted a bibliometric analysis including 12,027 studies related to the schizophrenia-serotonin link published from the inception of the study to 2023 and available in the Scopus database. We used VOSviewer software to identify global trends, analyse the author and editors keywords, the most cited articles and author, as well as the most productive institutes and journals publishing research on schizophrenia-serotonin link.ResultsMost publications related to the link between schizophrenia and serotonin are focused on adult humans and examine topics such as antipsychotic agents, depression, and serotonin uptake inhibitors. The Journal of Clinical Psychiatry has published the most papers on the schizophrenia-serotonin relationship. Among nations, the United States is the leader in publications. King's College London is the institution with the highest number of publications, and H. Y. Meltzer is the most influential author. Growing trends in schizophrenia-serotonin research are personalised medicine, alternative medicine, transcranial magnetic stimulation, artificial intelligence, nervous system inflammation, brain-gut axis, and the gut microbiome.ConclusionSince 1950, there have been several fluctuations in the number of published studies related to schizophrenia and serotonin. We believe that the development of novel medications and treatments for schizophrenia will be increased in the future, as well as research into genetic risks, psychological factors, and cranial neuroimaging components. Future schizophrenia and serotonin research is likely to focus on personalised medicine, alternative therapies, novel pathogenesis of schizophrenia, and the use of emerging technologies such as artificial intelligence.

Project description:The skin's integrity is vulnerable to external elements that can induce injuries, leading to wound formation. It's crucial to comprehend wound healing processes to protect the body when this protective barrier is compromised. Over the last 2 decades, there has been considerable progress in understanding delayed wound healing, with a focus on the mechanisms and microenvironmental factors involved. The connection between oxidative stress and wound healing has recently gained attention, emphasizing the need for in-depth analysis to propel further advancements and interventions in this area. Despite these advancements, there remains a noticeable void in the literature concerning the application of scientometric methods to systematically examine the progression of wound healing research. Additionally, a comprehensive assessment of the research output and effectiveness of various researchers and institutions in this field is lacking. To address these gaps, we analyzed data from the Web of Science Core Collection from January 1, 2000, to December 31, 2023, utilizing relevant keywords. Using CiteSpace, we created visual maps that depict the evolution and structure of keyword clusters, and both CiteSpace and VOSviewer were used to evaluate the performance of research networks across different countries, institutions, and authors. This data was methodically analyzed. The leading institution in this field is the Chinese Academy of Medical Sciences. The key researchers are Bekeschus, Sander; Li, Yang; Bi, Yang; Fan, Daidi; and Zhang, Yu. Our software analysis reviewed 3025 studies, revealing 19 co-citation clusters that highlight current trends in research on oxidative stress and wound healing. Prominent journals, leading institutions, and key researchers were identified. Key emerging research directions include studying the mechanisms linking oxidative stress to wound healing, exploring the use of antioxidant substances in wound dressings, and investigating how nanomaterials in dressings can influence oxidative stress. These focal points emphasize the significance of understanding oxidative stress's impact on wound healing and investigating new methods to enhance therapeutic efficacy. This comprehensive approach not only fills a gap in the current literature but also sets the stage for future research endeavors in this crucial area of health science.

Dataset Information

Schizophrenia and oxidative stress from the perspective of bibliometric analysis.

Background

Methods

Results

Conclusions

Publications

Schizophrenia and oxidative stress from the perspective of bibliometric analysis.

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