A novel approach to analyze the association characteristics between post-spliced introns and their corresponding mRNA.

ABSTRACT: Studies have shown that post-spliced introns promote cell survival when nutrients are scarce, and intron loss/gain can influence many stages of mRNA metabolism. However, few approaches are currently available to study the correlation between intron sequences and their corresponding mature mRNA sequences. Here, based on the results of the improved Smith-Waterman local alignment-based algorithm method (SW method) and binding free energy weighted local alignment algorithm method (BFE method), the optimal matched segments between introns and their corresponding mature mRNAs in Caenorhabditis elegans (C.elegans) and their relative matching frequency (RF) distributions were obtained. The results showed that although the distributions of relative matching frequencies on mRNAs obtained by t

SUBMITTER: Bo S 

PROVIDER: S-EPMC10008863 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature