Weighted gene co-expression network analysis identifies key hub genes and pathways in acute myeloid leukemia.

ABSTRACT: Introduction: Acute myeloid leukemia (AML) is the most common type of leukemia in adults. However, there is a gap in understanding the molecular basis of the disease, partly because key genes associated with AML have not been extensively explored. In the current study, we aimed to identify genes that have strong association with AML based on a cross-species integrative approach. Methods: We used Weighted Gene Co-Expression Network Analysis (WGCNA) to identify co-expressed gene modules significantly correlated with human AML, and further selected the genes exhibiting a significant difference in expression between AML and healthy mouse. Protein-protein interactions, transcription factors, gene function, genetic regulation, and coding sequence variants were integrated to identif

SUBMITTER: Wang X 

PROVIDER: S-EPMC10008864 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature