Genetic liability to mental disorders in relation to the risk of hypertension.

ABSTRACT:

Background

Observational studies have indicated that psychosocial factors contribute to hypertension; however, the causality of these associations remains unclear due to reverse causality and confounders. We aim to assess the causal associations of mental health disorders with hypertension.

Methods

Instrumental variables of anxiety disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, depression, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, and subjective well-being measure were obtained from the corresponding largest genome-wide association studies. Summary statistics for the association of essential hypertension were obtained from the FinnGen Study (42,857 cases and 162,837 controls) and UK Biobank cohort (54,358 cas

SUBMITTER: Huangfu N 

PROVIDER: S-EPMC10008891 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature