Integrated analysis of long non-coding RNAs and mRNAs associated with glaucoma in vitro.

ABSTRACT:

Introduction

In recent years, the biological functions and important roles of long non-coding RNAs (lncRNAs) have been widely reported in many diseases. Although glaucoma is the leading cause of blindness worldwide, the specific mechanisms of lncRNAs in the pathogenesis and progression of glaucoma remain unclear. Our research aims to elucidate the differentially expressed lncRNAs and mRNAs in glaucoma and to provide a basis for further exploration of the specific mechanism of action of lncRNAs in the progression of glaucoma.

Methods

We performed RNA sequencing on samples from a pressurized model of R28 cells and performed bioinformatics analyses on the sequencing results. The expression consistency of lncRNAs in clinical samples from patients with glaucoma or cataracts was d

SUBMITTER: You M 

PROVIDER: S-EPMC10008935 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature