Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction.

ABSTRACT: In this study, we addressed the functional significance of co-operative DNA binding of the cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) in an experimental murine model of acute myocardial infarction (MI). STAT1 knock-in mice expressing a phenylalanine-to-alanine substitution at position 77 in the STAT1 amino-terminal domain were examined for the early clinical effects produced by ligation of the left anterior descending coronary artery (LAD), an established model for MI. The F77A mutation has been previously reported to disrupt amino-terminal interactions between adjacent STAT1 dimers resulting in impaired tetramerization and defective co-operative binding on DNA, while leaving other protein functions unaffected. Our results demonstrate th

SUBMITTER: Doudin A 

PROVIDER: S-EPMC10008942 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature