Coordinated regulation of Cdc42ep1, actin, and septin filaments during neural crest cell migration.

ABSTRACT: The septin cytoskeleton has been demonstrated to interact with other cytoskeletal components to regulate various cellular processes, including cell migration. However, the mechanisms of how septin regulates cell migration are not fully understood. In this study, we use the highly migratory neural crest cells of frog embryos to examine the role of septin filaments in cell migration. We found that septin filaments are required for the proper migration of neural crest cells by controlling both the speed and the direction of cell migration. We further determined that septin filaments regulate these features of cell migration by interacting with actin stress fibers. In neural crest cells, septin filaments co-align with actin stress fibers, and the loss of septin filaments leads to impaired stab

SUBMITTER: Kho M 

PROVIDER: S-EPMC10009165 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature