Risk of coronary artery disease in patients with gout on treatment with Colchicine: A systematic review and meta-analysis

ABSTRACT:

Background

Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery disease (CAD).

Methods

Medline, Web of Science and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary outcomes included myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Secondary outcomes included stroke and all-cause mortality.

Results

We included 4 observational studies comprising 10,026 patients with gout on treatment with colchicine. There was no significant difference in the risk of myoc

SUBMITTER: Siddiqui M 

PROVIDER: S-EPMC10009207 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature