Risk factor analysis and construction of prediction models of gallbladder carcinoma in patients with gallstones.

ABSTRACT:

Background

Gallbladder carcinoma (GBC) is a biliary tract tumor with a high mortality rate. The objectives of this study were to explore the risk factors of GBC in patients with gallstones and to establish effective screening indicators.

Methods

A total of 588 patients from medical centers in two different regions of China were included in this study and defined as the internal test samples and the external validation samples, respectively. We retrospectively reviewed the differences in clinicopathologic data of the internal test samples to find the independent risk factors that affect the occurrence of GBC. Then, we constructed three different combined predictive factors (CPFs) through the weighting method, integral system, and nomogram, respectively, and named them CPF-A,

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10009222 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature