Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images.

ABSTRACT:

Objective

The blood-brain barrier (BBB) is an obstacle for molecules to pass through from blood to the brain. Focused ultrasound is a new method which temporarily opens the BBB, which makes pharmaceutical delivery or removal of neurodegenerative proteins possible. This study was demonstrated to review our BBB opening procedure with magnetic resonance guided images and find specific patterns in the BBB opening.

Methods

In this study, we reviewed the procedures and results of two clinical studies on BBB opening using focused ultrasound regarding its safety and clinical efficacy. Magnetic resonance images were also reviewed to discover any specific findings.

Results

Two clinical trials showed clinical benefits. All clinical trials demonstrated safe BBB opening, with no s

SUBMITTER: Chang KW 

PROVIDER: S-EPMC10009247 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature