Brief Report: Severe Pneumonitis After Combined Thoracic Radiotherapy and Osimertinib

ABSTRACT:

Introduction

Osimertinib is an effective treatment for metastatic NSCLC. Occasionally, thoracic radiation therapy (TRT) is delivered to patients receiving osimertinib to treat residual or progressing pulmonary tumors. Anecdotal reports suggest that the delivery of TRT in combination with osimertinib may be associated with a high risk of severe pneumonitis.

Methods

A retrospective study was performed at a single academic medical center in the United States to investigate the incidence of severe pneumonitis among patients treated with combined TRT and osimertinib between June 2016 and December 2021. Baseline patient characteristics, tumor size and location, and dosimetric parameters were evaluated. The highest grade of radiation pneumonitis that developed within 6 months of

SUBMITTER: Smith C 

PROVIDER: S-EPMC10009282 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature