Genetic alterations in CREBRF influence prostate cancer survival and impact prostate tissue homeostasis in mice.

ABSTRACT:

Background

Risk factors for prostate cancer include age, environment, race and ethnicity. Genetic variants in cyclic-adenosine-monophosphate-response-element-binding protein 3 regulatory factor (CREBRF) gene are frequently observed in Pacific Islanders, a population with elevated prostate cancer incidence. CREBRF has been shown to play a role in other cancers, however its function in prostate homeostasis and tumorigenesis has not been previously explored. We determined the incidence of CREBRF alterations in publicly available databases and examined the impact of CREBRF deletion on the murine prostate in order to determine whether CREBRF impacts prostate physiology or pathophysiology.

Methods

Alterations in CREBRF were identified in prostate cancer patients via in silico anal

SUBMITTER: Pascal LE 

PROVIDER: S-EPMC10009309 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature