Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes.

ABSTRACT:

Background

Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as endophenotypes for schizophrenia in twin and family studies. However, the genetic basis of the overlap between schizophrenia and these oculomotor markers is largely unknown. Here, we tested whether schizophrenia polygenic risk scores (PRS) were associated with oculomotor performance in the general population.

Methods

Analyses were based on the data of 2956 participants (aged 30-95) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Genotyping was performed on Omni-2.5 exome arrays. Using summary statistics from a recent met

SUBMITTER: Coors A 

PROVIDER: S-EPMC10009390 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature