Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study.

ABSTRACT:

Background

Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the therapeutic effects of some antipsychotics on sleep variables; however, to our knowledge, the effects of brexpiprazole on sleep architecture have not been examined in patients with schizophrenia. Therefore, we aimed to exploratorily investigate the effect of brexpiprazole on sleep variables measured by polysomnography in patients with schizophrenia.

Methods

This study included 10 patients with schizophrenia who were originally treated with haloperidol alone. Sleep variables of the participants were measured using polysomnography. After excluding those who did not meet the study criteria, seven patients (five men and two wo

SUBMITTER: Arai Y 

PROVIDER: S-EPMC10009411 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature