Cathelicidin promotes liver repair after acetaminophen-induced liver injury in mice.

ABSTRACT:

Background & aims

Acetaminophen (APAP)-induced acute liver injury (AILI) is a leading cause of acute liver failure (ALF). N-acetylcysteine (NAC) is only effective within 24 h after APAP intoxication, raising an urgent need for alternative approaches to treat this disease. This study aimed to test whether cathelicidin (Camp), which is a protective factor in chronic liver diseases, protects mice against APAP-induced liver injury and ALF.

Methods

A clinically relevant AILI model and an APAP-induced ALF model were generated in mice. Genetic and pharmacological approaches were used to interfere with the levels of cathelicidin in vivo.

Results

An increase in hepatic pro-CRAMP/CRAMP (the precursor and mature forms of mouse cathelicidin) was observed in A

SUBMITTER: Zhai T 

PROVIDER: S-EPMC10009536 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature