The orexinergic system mediates the excitatory effects of caffeine on the arousal and sympathetic activity.

ABSTRACT:

Objective

Caffeine is a non-selective adenosine receptor antagonist with pro-arousal and pro-sympathetic nervous system excitatory effects, and these pharmacological effects fit well with the physiological functions of orexin. The purpose of this study was to investigate the role of the orexinergic nervous system in the pharmacological effects of caffeine.

Methods

An animal model of sleepiness caused by adenosine accumulation was established by sleep deprivation, and caffeine's effects on the spontaneous activity and sympathetic nervous system of the model animals were evaluated by using the open-field experiment and gastrointestinal peristaltic observation, respectively, and the intervention of orexin receptor antagonists on the pharmacological effects of caffeine was also

SUBMITTER: Li Y 

PROVIDER: S-EPMC10009538 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature