Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.

ABSTRACT: Pathogenic mechanisms in degenerative thoracic aortic aneurysms (TAA) are still unclear. There is an ongoing debate about whether TAAs are caused by uniform or distinct processes, which would obviously have a major impact on future treatment strategies. Clearly, the ultimate outcome of TAA subgroups associated with a tricuspid aortic valve (TAV) or a bicuspid aortic valve (BAV) is the same, namely a TAA. Based on results from our own and others' studies, we decided to compare the different TAAs (TAV and BAV) and controls using a broad array of analyses, i.e., metabolomic analyses, gene expression profiling, protein expression analyses, histological characterization, and matrix-assisted laser desorption ionization imaging. Central findings of the present study are the presence of noncanonic

SUBMITTER: Doppler C 

PROVIDER: S-EPMC10009546 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature