Soluble ST2 Predicts Poor Functional Outcome in Acute Ischemic Stroke Patients.

ABSTRACT:

Introduction

There are very limited data on the role of biomarkers correlating with the outcome in acute ischemic stroke (AIS). We evaluated the predictive values of the plasma concentrations of soluble serum stimulation-2 (sST2), matrix metalloproteinase-9 (MMP-9), and claudin-5 in AIS.

Methods

The biomarker levels in the plasma samples of consecutive AIS patients collected at baseline, 12 h, and 24 h from stroke onset were quantified using immunoassays. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and functional outcome at 90 days using the modified Rankin Scale (mRS), with scores above 3 defined as poor outcome. Receiver operating characteristic curve analysis and multiple logistic regression were performed for evaluating the d

SUBMITTER: Krishnamoorthy S 

PROVIDER: S-EPMC10009551 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature