Identification of ferroptosis-related genes in ulcerative colitis: a diagnostic model with machine learning.

ABSTRACT:

Background

Ulcerative colitis (UC) is an idiopathic, chronic disorder characterized by inflammation, injury, and disruption of the colonic mucosa. However, there are still many difficulties in the diagnosis and differential diagnosis of UC. An increasing amount of research has shown a connection between ferroptosis and the etiology of UC. Therefore, our study aimed to identify the key genes related to ferroptosis in UC to provide new ideas for diagnosis UC.

Methods

Gene expression profiles of normal and UC samples were extracted from the Gene Expression Omnibus (GEO) database. By combining differentially expressed genes (DEGs), Weighted correlation network analysis (WGCNA) genes, and ferroptosis-related genes, hub genes were identified and then screened using Lasso regressio

SUBMITTER: Qian R 

PROVIDER: S-EPMC10009563 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature