E2F1 inhibits cellular senescence and promotes oxaliplatin resistance in colorectal cancer.

ABSTRACT:

Background

Doctors have always been overwhelmed by tumor drug resistance because it is a major challenge in the clinical treatment of tumors. Cellular senescence has a strong relationship with the development of tumor drug resistance. Herein, we aimed to explore new regulatory factors involved in the aging process of colorectal cancer (CRC) cells and assess the effect of cellular senescence on CRC drug resistance.

Methods

Genes associated with cellular senescence for anticipating regulatory factors were first used, and the regulatory molecules of survival significance were then identified based on the results of public database analysis. The effects of E2F translation factor 1 (E2F1) on CRC cell viability, invasion, migration, and cellular senescence processes were assessed

SUBMITTER: Gao H 

PROVIDER: S-EPMC10009566 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature