NCOA2-induced secretion of leptin leads to fetal growth restriction via the NF-κB signaling pathway.

ABSTRACT:

Background

Fetal growth restriction (FGR) is one of the most common fetal complications during pregnancy in the obstetrics department, with poor therapeutic efficacy. The local inflammatory response of the placenta has gradually become known as the main mechanism for the occurrence and development of FGR. The aim of this study was to improve the knowledge of placental inflammatory response mechanisms in regulating gene expression.

Methods

The differentially expressed genes (DEGs) in FGR patients were analyzed through bioinformatics analysis. The expression of gene level was detected by immunohistochemistry (IHC) staining, quantitative polymerase chain reaction (qPCR), or enzyme-linked immunosorbent assay (ELISA). The proliferation, migration, and apoptosis of HTR-8/SVneo tro

SUBMITTER: Qu L 

PROVIDER: S-EPMC10009567 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature