Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease.

ABSTRACT:

Background

In lean individuals, nonalcoholic fatty liver disease (NAFLD) is not a benign disease, and these patients have long-term morbidity and mortality similar to those of their nonlean counterparts. Finding biomarkers for noninvasive and early detection is urgent and microRNAs (miRNAs) show potential. The aims of this study were to investigate the potential role of serum miRNAs in the detection of lean NAFLD and to explore the possible pathogenesis of lean NAFLD.

Methods

A total of 498 patients with NAFLD and 98 healthy controls were included to compare the clinical characteristics of lean NAFLD patients [LNs: body mass index (BMI) <23 kg/m²], nonlean NAFLD patients (NLNs: BMI ≥23 kg/m²) and normal healthy individuals (HIs). A total of 14 serum sam

SUBMITTER: Shen N 

PROVIDER: S-EPMC10009574 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature