Exploration of prognostic biomarkers in head and neck squamous cell carcinoma microenvironment from TCGA database.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) therapies have redefined human cancer treatment, including for head and neck squamous cell carcinoma (HNSCC). However, clinical responses to various immune checkpoint inhibitors are often accompanied by immune-related adverse events (irAEs). Therefore, it is crucial to obtain a comprehensive understanding of the association between different immune tumor microenvironments (TMEs) and the immunotherapeutic response.

Methods

The research data were obtained from The Cancer Genome Atlas (TCGA) database. We applied RNA-seq genomic data from tumor biopsies to assess the immune TME in HNSCC. As the TME is a heterogeneous system that is highly associated with HNSCC progression and clinical outcome, we relied on the Estimation of Stromal and

SUBMITTER: Li Y 

PROVIDER: S-EPMC10009575 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature