Laxative effect of Wenyang Yiqi Decoction on loperamide-induced astriction model mice.

ABSTRACT:

Background

Although a common disease, astriction is difficult to treat and severely affects quality of life. Wenyang Yiqi Decoction (WYD) is a kind of traditional Chinese medicine (TCM) that is used to treat astriction; however, the mechanism remains unclear. Therefore, this work assessed the laxative effect of WYD on loperamide-induced astriction (LIA) model mice.

Methods

We replicated a constipation model in mice and detected changes in fecal parameters such as feces quantity and water content, intestinal transit function, and histopathological changes in the constipated mice. After five days of WYD intervention, mouse tissues were taken out for detection. We also measured the levels of gastrin (Gas), substance P (SP), acetylcholinesterase (AChE), and vasoactive intestinal

SUBMITTER: Su Y 

PROVIDER: S-EPMC10009577 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature