Esophageal cancer-related gene 4 inhibits gastric cancer growth and metastasis by upregulating Kruppel-like factor 2 expression.

ABSTRACT:

Background

There are a large number of people suffering from gastric cancer (GC) worldwide, so the study of biomarkers for GC is urgently needed. This study aimed to investigate the role of esophageal cancer-related gene 4 (ECRG4) in the growth, metastasis, and prognosis of GC and the possible underlying mechanism.

Methods

The expression of ECRG4 was detected in GC tissues by quantitative polymerase chain reaction (PCR), Western blot, and immunohistochemistry. The relationships between ECRG4 expression and clinicopathological parameters of patients with GC were statistically analyzed, and Kaplan-Meier prognosis and survival curves of the patients were plotted. ECRG4 was overexpressed in the human gastric adenocarcinoma cell line (AGS) and human GC cell line 27 (HGC27), and t

SUBMITTER: Li X 

PROVIDER: S-EPMC10009579 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature